RESUMO
Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Clinical exam revealed no other evidence of lymphoma, the patient denied constitutional symptoms, and routine blood work was normal. The patient is healthy and doing well 28 months after her first visit. CD30+ pseudolymphoma should be distinguished from malignant intravascular lymphoproliferative disorders.
Assuntos
Ceratoacantoma/patologia , Pseudolinfoma/patologia , Dermatopatias/patologia , Idoso , Ligante CD30/imunologia , Diagnóstico Diferencial , Feminino , Humanos , Ceratoacantoma/diagnóstico , Ceratoacantoma/imunologia , Linfoma de Células T/diagnóstico , Linfoma de Células T/patologia , Pseudolinfoma/diagnóstico , Pseudolinfoma/imunologia , Dermatopatias/diagnóstico , Dermatopatias/imunologia , Linfócitos T/imunologia , Linfócitos T/patologiaRESUMO
Skin of color (SOC) populations (ie, blacks, Hispanics, Asians) are at a notably higher risk for mortality from skin cancers such as melanoma than white individuals. In this article, we seek to answer the following question: Do knowledge-based interventions increase skin cancer awareness among SOC patients? Following an extensive literature search, a total of 4 articles were analyzed and discussed in this review.
Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Melanoma/prevenção & controle , Educação de Pacientes como Assunto , Neoplasias Cutâneas/prevenção & controle , Etnicidade , Humanos , Melanoma/etnologia , Neoplasias Cutâneas/etnologiaAssuntos
Compostos de Boro/uso terapêutico , Compostos Bicíclicos Heterocíclicos com Pontes/uso terapêutico , Dermatite Atópica/tratamento farmacológico , Fármacos Dermatológicos/uso terapêutico , Administração Cutânea , Compostos de Boro/efeitos adversos , Compostos Bicíclicos Heterocíclicos com Pontes/efeitos adversos , Dermatite Atópica/patologia , Fármacos Dermatológicos/efeitos adversos , HumanosAssuntos
Negro ou Afro-Americano/estatística & dados numéricos , Melanoma/terapia , Neoplasias Cutâneas/terapia , Raios Ultravioleta/efeitos adversos , População Branca/estatística & dados numéricos , Compreensão , Feminino , Humanos , Masculino , Melanoma/mortalidade , Melanoma/patologia , Determinação de Necessidades de Cuidados de Saúde , Medição de Risco , Neoplasias Cutâneas/mortalidade , Neoplasias Cutâneas/patologia , Pigmentação da Pele/fisiologia , Pigmentação da Pele/efeitos da radiação , Análise de Sobrevida , Estados UnidosRESUMO
The well-characterized cellular and structural components of the kidney show distinct regional compositions and distribution of lipids. In order to more fully analyze the renal lipidome we developed a matrix-assisted laser desorption/ionization mass spectrometry approach for imaging that may be used to pinpoint sites of changes from normal in pathological conditions. This was accomplished by implanting sagittal cryostat rat kidney sections with a stable, quantifiable and reproducible uniform layer of silver using a magnetron sputtering source to form silver nanoparticles. Thirty-eight lipid species including seven ceramides, eight diacylglycerols, 22 triacylglycerols, and cholesterol were detected and imaged in positive ion mode. Thirty-six lipid species consisting of seven sphingomyelins, 10 phosphatidylethanolamines, one phosphatidylglycerol, seven phosphatidylinositols, and 11 sulfatides were imaged in negative ion mode for a total of seventy-four high-resolution lipidome maps of the normal kidney. Thus, our approach is a powerful tool not only for studying structural changes in animal models of disease, but also for diagnosing and tracking stages of disease in human kidney tissue biopsies.